Pulse Brain · Growing Health Evidence Index
Peer-reviewed

The Role of Tumor Biomarkers in Tailoring the Approach to Advanced Ovarian Cancer

Noemi Tonti, Tullio Golia D’Augè, Ilaria Cuccu, Emanuele De Angelis, Ottavia D’Oria, Giorgia Perniola, Antonio Simone Laganà, Andrea Etrusco, Federico Ferrari, Stefania Saponara, Violante Di Donato, Giorgio Bogani, Andrea Giannini

International Journal of Molecular Sciences · 2024

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Summary

Growing evidence has demonstrated the role of mutations of tumor biomarkers in diagnosing and treating epithelial ovarian cancer. This review aims to analyze recent literature on the correlation between tumor biomarkers and chemotherapy in nonmucinous ovarian cancer, providing suggestions for personalized treatment approaches. An extensive literature search was conducted to identify relevant studies and trials. <i>BRCA1/2</i> mutations are central in homologous recombination repair deficiency (HRD) in ovarian cancer, but several other genetic mutations also contribute to varying cancer risks. While the role of MMR testing in ovarian cancer is debated, it is more commonly linked to non-serous ovarian cancer, often associated with Lynch syndrome. A significant proportion of ovarian cancer pa

Source type
Peer-reviewed study
DOI
10.3390/ijms252011239
Catalogue ID
SNmoht1vsb-pwno9r
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