Pulse Brain · Growing Health Evidence Index
Peer-reviewed

The diagnostic and prognostic significance of HOXC13-AS and its molecular regulatory mechanism in human cancer

Xiaosi Gu, Xin Hu, Sijia Zhang, Xiaoyu Zhang, Yong Wang, Lianlian Li

Frontiers in Molecular Biosciences · 2025

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Summary

HOXC13 antisense RNA (HOXC13-AS, also known as HOXC-AS5) is a long non-coding RNA that is expressed abnormally in various types of tumors and is closely related to clinical staging, clinical pathological features, and patient survival. HOXC13-AS is involved in the occurrence and development of tumors, affecting cell proliferation, migration, invasion, epithelial-mesenchymal transition, and tumor growth. This review summarizes the clinical significance of HOXC13-AS as a biomarker for human tumor diagnosis and prognosis and outlines the function and molecular regulation mechanism of HOXC13-AS in various types of cancer, including nasopharyngeal carcinoma, breast cancer, oral squamous cell carcinoma, glioma, and cervical cancer. Overall, this review emphasizes the potential of HOXC13-AS as a

Source type
Peer-reviewed study
DOI
10.3389/fmolb.2025.1540048
Catalogue ID
SNmoi53i17-nyjm4i
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