Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Circulating miR-16-5p, miR-92a-3p, and miR-451a in Plasma from Lung Cancer Patients: Potential Application in Early Detection and a Regulatory Role in Tumorigenesis Pathways

Patrícia P. Reis, Sandra A. Drigo, Robson Francisco Carvalho, Rainer Marco López Lapa, Tainara F. Felix, Devalben Patel, Dangxiao Cheng, Melania Pintilie, Geoffrey Liu, Ming‐Sound Tsao

Cancers · 2020

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Summary

The 3-miRNA signature (miR-16-5p, miR-92a-3p, miR-451a) had high specificity (100%) and sensitivity (84%) to predict cancer (LUAD and LUSC). These miRNAs are predicted to modulate genes and pathways with known roles in lung tumorigenesis, including <i>EGFR</i>, <i>K-RAS</i>, and <i>PI3K/AKT</i> signaling, suggesting that the 3-miRNA signature is biologically relevant in adenocarcinoma and squamous cell carcinoma of the lung.

Source type
Peer-reviewed study
DOI
10.3390/cancers12082071
Catalogue ID
SNmoi53j2u-uizxyu
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