Summary
This 2017 review in Gastroenterology synthesises knowledge of genomic and epigenomic alterations in oesophageal squamous cell carcinoma, a major human malignancy with high mortality. The authors examine molecular aberrations identified through contemporary research and discuss their clinical implications for patient stratification and therapeutic decision-making. The work appears intended to inform precision medicine approaches based on molecular profiling of this disease.
UK applicability
Whilst oesophageal squamous cell carcinoma is less common in the UK than in East Asia, understanding genomic drivers may inform prevention and treatment strategies for affected UK patients. The review's molecular insights are clinically relevant to UK oncology and gastroenterology practice, though UK-specific epidemiological or aetiological factors are not discussed.
Key measures
Genomic aberrations, epigenomic modifications, molecular alterations in oesophageal squamous cell carcinoma
Outcomes reported
The review synthesises current understanding of genomic and epigenomic alterations associated with oesophageal squamous cell carcinoma, examining molecular aberrations and their clinical implications for patient stratification and therapeutic approaches.
Topic tags
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