Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Organ aging signatures in the plasma proteome track health and disease

Hamilton Oh, Jarod Rutledge, Daniel Nachun, Róbert Pálovics, Olamide Abiose, Patricia Moran‐Losada, Divya Channappa, Deniz Yagmur Urey, K. Kim, Yun Ju Sung, Lihua Wang, Jigyasha Timsina, Daniel Western, Menghan Liu, Pat Kohlfeld, John Budde, Edward N. Wilson, Yann Le Guen, Taylor Maurer, Michael S. Haney, Andrew C. Yang, Zihuai He, Michael D. Greicius, Katrin I. Andreasson, Sanish Sathyan, Erica Weiss, Sofiya Milman, Nir Barzilai, Carlos Cruchaga, Anthony D. Wagner, Elizabeth C. Mormino, Benoit Lehallier, Victor W. Henderson, Frank M. Longo, Stephen B. Montgomery, Tony Wyss‐Coray

Nature · 2023

Read source ↗ All evidence

Summary

), the current best blood-based biomarker for AD. Our models link vascular calcification, extracellular matrix alterations and synaptic protein shedding to early cognitive decline. We introduce a simple and interpretable method to study organ aging using plasma proteomics data, predicting diseases and aging effects.

Source type
Peer-reviewed study
DOI
10.1038/s41586-023-06802-1
Catalogue ID
SNmoixntmk-oui4rq
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