Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Aging activates escape of the silent X chromosome in the female mouse hippocampus

Margaret Gadek, Cayce K. Shaw, Samira Abdulai-Saiku, Rowan Saloner, Francesca Marino, Dan Wang, Luke W. Bonham, Jennifer S. Yokoyama, Barbara Panning, Bérénice A. Benayoun, Kaitlin B. Casaletto, Vijay Ramani, Dena B. Dubal

Science Advances · 2025

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Summary

elevation in the dentate gyrus of aging male and female mice improved cognition. Understanding how the Xi may confer female advantage could lead to novel targets that counter brain aging and disease in both sexes.

Source type
Peer-reviewed study
DOI
10.1126/sciadv.ads8169
Catalogue ID
SNmoixnvjy-2alamy
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