Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging

Daniel B. Rosoff, Lucas A. Mavromatis, Andrew S. Bell, Josephin Wagner, Jeesun Jung, Riccardo E. Marioni, George Davey Smith, Steve Horvath, Falk W. Lohoff

Nature Aging · 2023

Read source ↗ All evidence

Summary

), angiopoietin-like protein 4, beta blockers and calcium channel blockers also had beneficial Mendelian randomization estimates. Extending the drug-target Mendelian randomization framework to 3,947 protein-coding genes prioritized 122 targets. Together, these findings will inform future studies aimed at improving healthy aging.

Source type
Peer-reviewed study
DOI
10.1038/s43587-023-00455-5
Catalogue ID
SNmoixnwcs-g1knuz
Pulse AI · ask about this record

Dig deeper with Pulse AI.

Pulse AI has read the whole catalogue. Ask about this record, its theme, or how the findings apply to UK farming and policy — every answer cites the underlying studies.

How does this finding apply in a UK context?→What are the most cited records on this topic?→