Summary
Background: Recent studies have suggested an association between gut microbiomes (GMs) and epilepsy. However, the GM taxa identified in different studies are variable. In addition, observational studies cannot indicate causality. Therefore, our study aimed to explore the causal association of GMs with epilepsy and identify the most influential GM taxa. Methods: -test, MR-Egger intercept test, MR-PRESSO global test, and leave-one-out analysis. Results: > 0.05). Finally, the leave-one-out analysis suggested the robustness of the results. Conclusion: Through the MR study, we analyzed the causal relationship of 211 GM taxa with epilepsy and determined the specific intestinal flora associated with increased epilepsy risk. Our findings may provide helpful biomarkers for disease progression and p
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