Cell types of origin of the cell-free transcriptome

Sevahn K. Vorperian, Mira N. Moufarrej, Overall Project Direction and Coordination, Robert C. Jones, Jim Karkanias, Mark A. Krasnow, Angela Oliveira Pisco, Stephen R. Quake, Julia Salzman, Nir Yosef, Donor Recruitment, Bryan Bulthaup, Phillip Brown, William Harper, Marisa Hemenez, Ravikumar Ponnusamy, Ahmad Salehi, Bhavani A. Sanagavarapu, Eileen Spallino, Surgeons, Ksenia A. Aaron, Waldo Concepcion, James M. Gardner, Burnett S. Kelly, Nikole Neidlinger, Zifa Wang, Logistical coordination, Sheela Crasta, Saroja Kolluru, Maurizio Morri, Serena Y. Tan, Kyle J. Travaglini, Chenling Xu, Organ Processing, Marcela Alcántara‐Hernández, Nicole Almanzar, Jane Antony, Benjamin Beyersdorf, Deviana Burhan, Kruti Calcuttawala, Matthew M. Carter, Charles K. F. Chan, Charles Chang, Stephen Chang, Alex Colville, Rebecca N. Culver, Ivana Cvijović, Gaetano D’Amato, Camille Ezran, Francisco X. Galdos, Astrid Gillich, William R. Goodyer, Yan Hang, Alyssa Hayashi, Sahar Houshdaran, Xianxi Huang, Juan C. Irwin, SoRi Jang, Júlia Vallvé-Juanico, Aaron M. Kershner, Soochi Kim, Bernhard Kiss, William Kong, Maya E. Kumar, Angera H. Kuo, Rebecca Leylek, Baoxiang Li, Gabriel B. Loeb, Wan-Jin Lu, Sruthi Mantri, Maxim Markovic, Patrick L. McAlpine, Antoine de Morrée, Karim Mrouj, Shravani Mukherjee, Tyler Muser, Patrick Neuhöfer, Thi D. Nguyen, Kimberly Perez, Ragini Phansalkar, Nazan Puluca, Zhen Qi, Poorvi Rao, Hayley M. Raquer-McKay, Nicholas Schaum, Bronwyn Scott, Bobak Seddighzadeh, Joe M. Segal, Sushmita Sen, Shaheen S. Sikandar, Sean P. Spencer, L.C. Steffes, Varun Ramanan Subramaniam, Aditi Swarup, Michael Swift, Will Van Treuren, Emily Trimm, Stefan Veizades, Sivakamasundari Vijayakumar, Kim Chi Vo

Nature Biotechnology · 2022

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Summary

Cell-free RNA from liquid biopsies can be analyzed to determine disease tissue of origin. We extend this concept to identify cell types of origin using the Tabula Sapiens transcriptomic cell atlas as well as individual tissue transcriptomic cell atlases in combination with the Human Protein Atlas RNA consensus dataset. We define cell type signature scores, which allow the inference of cell types that contribute to cell-free RNA for a variety of diseases.

Source type: Peer-reviewed study
DOI: 10.1038/s41587-021-01188-9
Catalogue ID: SNmoj1yi92-5oz1t1

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