Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver

Paola Dongiovanni, Stefan Stender, Alessandro Pietrelli, Rosellina Margherita Mancina, Annalisa Cespiati, Salvatore Petta, Serena Pelusi, Piero Pingitore, Sara Badiali, Marco Maggioni, Ville Männistö, Stefania Grimaudo, Rosaria Maria Pipitone, Jussi Pihlajamäki, Antonio Craxı̀, Magdalena Taube, Lena Carlsson, Silvia Fargion, Stefano Romeo, Julia Kozlitina, Luca Valenti

Journal of Internal Medicine · 2017

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Summary

BACKGROUND AND AIMS: Nonalcoholic fatty liver disease is epidemiologically associated with hepatic and metabolic disorders. The aim of this study was to examine whether hepatic fat accumulation has a causal role in determining liver damage and insulin resistance. METHODS: We performed a Mendelian randomization analysis using risk alleles in PNPLA3, TM6SF2, GCKR and MBOAT7, and a polygenic risk score for hepatic fat, as instruments. We evaluated complementary cohorts of at-risk individuals and individuals from the general population: 1515 from the liver biopsy cohort (LBC), 3329 from the Swedish Obese Subjects Study (SOS) and 4570 from the population-based Dallas Heart Study (DHS). RESULTS: Hepatic fat was epidemiologically associated with liver damage, insulin resistance, dyslipidemia and

Source type
Peer-reviewed study
DOI
10.1111/joim.12719
Catalogue ID
SNmoj440qw-lp9n6t
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