Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Inhibition of NLRP3 Inflammasome: A Prospective Target for the Treatment of Ischemic Stroke

Ya-Shuo Feng, Zixuan Tan, Manman Wang, Ying Xing, Fang Dong, Feng Zhang

Frontiers in Cellular Neuroscience · 2020

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Summary

Stroke is one of the major devastating diseases with no effective medical therapeutics. Because of the high rate of disability and mortality among stroke patients, new treatments are urgently required to decrease brain damage following a stroke. In recent years, the inflammasome is a novel breakthrough point that plays an important role in the stroke, and the inhibition of inflammasome may be an effective method for stroke treatment. Briefly, inflammasome is a multi-protein complex that causes activation of caspase-1 and subsequent production of pro-inflammatory factors including interleukin (IL)-18 and IL-1β. Among them, the NLRP3 inflammasome is the most typical inflammasome, which can detect cell damage and mediate inflammatory response to tissue damage in ischemic stroke. The NLRP3 inf

Source type
Peer-reviewed study
DOI
10.3389/fncel.2020.00155
Catalogue ID
SNmoj443jx-sp6av8
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