Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Low-density lipoprotein particles in atherosclerosis

Yanan Qiao, Yanli Zou, Shoudong Guo

Frontiers in Physiology · 2022

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Summary

Among the diseases causing human death, cardiovascular disease (CVD) remains number one according to the World Health Organization report in 2021. It is known that atherosclerosis is the pathological basis of CVD. Low-density lipoprotein (LDL) plays a pivotal role in the initiation and progression of atherosclerotic CVD (ASCVD). LDL cholesterol (LDL-C) is the traditional biological marker of LDL. However, large numbers of patients who have achieved the recommended LDL-C goals still have ASCVD risk. In multiple prospective studies, LDL particle (LDL-P) is reported to be more accurate in predicting CVD risk than LDL-C. LDL-Ps differ in size, density and chemical composition. Numerous clinical studies have proved that the atherogenic mechanisms of LDL-Ps are determined not only by LDL number

Source type
Peer-reviewed study
DOI
10.3389/fphys.2022.931931
Catalogue ID
SNmoj444fq-xq9xh0
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