Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Lipids Metabolism Inhibition Antiproliferative Synergy with 5-Fluorouracil in Human Colorectal Cancer Model

Judyta Zabielska, Ewa Stelmańska, Sylwia Szrok-Jurga, Jarek Kobiela, Aleksandra Czumaj

International Journal of Molecular Sciences · 2025

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Summary

< 0.001), respectively. The association of 5-FU with Lovastatin (HMGCR inhibitor) did not significantly impact CRC cell viability in a synergistic manner. Inhibition of lipid metabolism combined with standard chemotherapy is a promising strategy that reduces CRC cell viability and allows for the use of a lower drug dose. The combination of 5-FU and Avasimibe has the greatest therapeutic potential among studied compounds.

Source type
Peer-reviewed study
DOI
10.3390/ijms26031186
Catalogue ID
SNmoj445k9-ir0sy2
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