Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Alcohol intake and cause-specific mortality: conventional and genetic evidence in a prospective cohort study of 512 000 adults in China

Iona Y. Millwood, Pek Kei Im, Derrick Bennett, Parisa Hariri, Ling Yang, Huaidong Du, Christiana Kartsonaki, Kuang Lin, Canqing Yu, Yiping Chen, Dianjianyi Sun, Ningmei Zhang, Daniel Avery, Dan Schmidt, Pei Pei, Junshi Chen, Robert Clarke, Jun Lv, Richard Peto, Robin Walters, Liming Li, Zhengming Chen

The Lancet Public Health · 2023

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Summary

BACKGROUND: Genetic variants that affect alcohol use in East Asian populations could help assess the causal effects of alcohol consumption on cause-specific mortality. We aimed to investigate the associations between alcohol intake and cause-specific mortality using conventional and genetic epidemiological methods among more than 512 000 adults in China. METHODS: The prospective China Kadoorie Biobank cohort study enrolled 512 724 adults (210 205 men and 302 519 women) aged 30-79 years, during 2004-08. Residents with no major disabilities from ten diverse urban and rural areas of China were invited to participate, and alcohol use was self-reported. During 12 years of follow-up, 56 550 deaths were recorded through linkage to death registries, including 23 457 deaths among 168 050 participan

Source type
Peer-reviewed study
DOI
10.1016/s2468-2667(23)00217-7
Catalogue ID
SNmoj448pl-1h1ygn
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