Jan Bělohlávek, Jana Šmalcová, Daniel Rob, Ondřej Franěk, Ondřej Šmíd, Milana Pokorná, J Horák, Vratislav Mrázek, Tomáš Kovárník, David Zemánek, Aleš Král, Štěpán Havránek, Petra Kaválková, Lucie Kompelentova, Helena Tomková, Alan Mejstrik, Jaroslav Valasek, David Peřan, Jaroslav Pekara, Jan Rulíšek, Martin Balík, Michal Huptych, Jiří Jarkovský, Jan Malík, Anna Valeriánová, František Mlejnský, Petr Kolouch, Petra Havránková, Dan Romportl, Arnošt Komárek, Aleš Linhart, Prague OHCA Study Group, Michael Aschermann, Petr Jeřábek, Michal Paďour, Jan Šimek, Michal Otáhal, Marek Flaksa, Ilona Lálová, Markéta Hubatová, Michal Pořízka, Hana Skalická

doi:10.1001/jama.2022.1025

Effect of Intra-arrest Transport, Extracorporeal Cardiopulmonary Resuscitation, and Immediate Invasive Assessment and Treatment on Functional Neurologic Outcome in Refractory Out-of-Hospital Cardiac Arrest

Jan Bělohlávek, Jana Šmalcová, Daniel Rob, Ondřej Franěk, Ondřej Šmíd, Milana Pokorná, J Horák, Vratislav Mrázek, Tomáš Kovárník, David Zemánek, Aleš Král, Štěpán Havránek, Petra Kaválková, Lucie Kompelentova, Helena Tomková, Alan Mejstrik, Jaroslav Valasek, David Peřan, Jaroslav Pekara, Jan Rulíšek, Martin Balík, Michal Huptych, Jiří Jarkovský, Jan Malík, Anna Valeriánová, František Mlejnský, Petr Kolouch, Petra Havránková, Dan Romportl, Arnošt Komárek, Aleš Linhart, Prague OHCA Study Group, Michael Aschermann, Petr Jeřábek, Michal Paďour, Jan Šimek, Michal Otáhal, Marek Flaksa, Ilona Lálová, Markéta Hubatová, Michal Pořízka, Hana Skalická

JAMA · 2022

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Summary

Importance: Out-of-hospital cardiac arrest (OHCA) has poor outcome. Whether intra-arrest transport, extracorporeal cardiopulmonary resuscitation (ECPR), and immediate invasive assessment and treatment (invasive strategy) is beneficial in this setting remains uncertain. Objective: To determine whether an early invasive approach in adults with refractory OHCA improves neurologically favorable survival. Design, Setting, and Participants: Single-center, randomized clinical trial in Prague, Czech Republic, of adults with a witnessed OHCA of presumed cardiac origin without return of spontaneous circulation. A total of 256 participants, of a planned sample size of 285, were enrolled between March 2013 and October 2020. Patients were observed until death or day 180 (last patient follow-up ended on

Source type: Peer-reviewed study
DOI: 10.1001/jama.2022.1025
Catalogue ID: SNmoj449kk-mnyt77

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