Catharina A. Hartman, Henrik Larsson, Melissa Vos, Alessio Bellato, Berit Libutzki, Berit Skretting Solberg, Qi Chen, Ebba Du Rietz, Jeanette C. Mostert, Sarah Kittel‐Schneider, Bru Cormand, Marta Ribasès, Kari Klungsøyr, Jan Haavik, Søren Dalsgaard, Samuele Cortese, Stephen V. Faraone, Andreas Reif

doi:10.1016/j.neubiorev.2023.105209

Summary

Knowledge on psychiatric comorbidity in adult ADHD is essential for prevention, detection, and treatment of these conditions. This review (1) focuses on large studies (n > 10,000; surveys, claims data, population registries) to identify (a) overall, (b) sex- and (c) age-specific patterns of comorbidity of anxiety disorders (ADs), major depressive disorder (MDD), bipolar disorder (BD) and substance use disorders (SUDs) in adults with ADHD relative to adults without ADHD; and (2) describes methodological challenges relating to establishing comorbidity in ADHD in adults as well as priorities for future research. Meta-analyses (ADHD: n = 550,748; no ADHD n = 14,546,814) yielded pooled odds ratios of 5.0(CI:3.29-7.46) for ADs, 4.5(CI:2.44-8.34) for MDD, 8.7(CI:5.47-13.89) for BD and 4.6(CI:2.72

Source type: Peer-reviewed study
DOI: 10.1016/j.neubiorev.2023.105209
Catalogue ID: SNmoj7nsmc-f0m99s

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Anxiety, mood, and substance use disorders in adult men and women with and without attention-deficit/hyperactivity disorder: A substantive and methodological overview

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