Pulse Brain · Growing Health Evidence Index
Peer-reviewed

A comparison of the genes and genesets identified by GWAS and EWAS of fifteen complex traits

Thomas Battram, Tom R. Gaunt, Caroline L. Relton, Nicholas J. Timpson, Gibran Hemani

Nature Communications · 2022

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Summary

; term overlap P = 0.001). We superimpose our empirical findings against simulated models of varying genetic and epigenetic architectures and observe that in most cases GWAS and EWAS are likely capturing distinct genesets. Our results indicate that GWAS and EWAS are capturing different aspects of the biology of complex traits.

Source type
Peer-reviewed study
DOI
10.1038/s41467-022-35037-3
Catalogue ID
SNmoj7nw4v-hkivtb
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