Lara Lechner, Robert Opitz, Matt J. Silver, Philipp Krabusch, Andrew M. Prentice, Martha S. Field, Harald Stachelscheid, Elsa Leitão, Christopher Schröder, Valeria Fernández Vallone, Bernhard Horsthemke, Karl‐Heinz Jöckel, Börge Schmidt, Markus M. Nöthen, Per Hoffmann, Stefan Herms, Patrick W. Kleyn, Matthias Megges, Ulrike Blume‐Peytavi, Katja Weiß, Knut Mai, Oliver Blankenstein, Benedikt Obermayer, Susanna Wiegand, Peter Kühnen

doi:10.1126/scitranslmed.adg1659

Early-set POMC methylation variability is accompanied by increased risk for obesity and is addressable by MC4R agonist treatment

Lara Lechner, Robert Opitz, Matt J. Silver, Philipp Krabusch, Andrew M. Prentice, Martha S. Field, Harald Stachelscheid, Elsa Leitão, Christopher Schröder, Valeria Fernández Vallone, Bernhard Horsthemke, Karl‐Heinz Jöckel, Börge Schmidt, Markus M. Nöthen, Per Hoffmann, Stefan Herms, Patrick W. Kleyn, Matthias Megges, Ulrike Blume‐Peytavi, Katja Weiß, Knut Mai, Oliver Blankenstein, Benedikt Obermayer, Susanna Wiegand, Peter Kühnen

Science Translational Medicine · 2023

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Summary

gene fulfilling the criteria for a metastable epiallele established in early embryonic development that may be addressable by MC4R agonist treatment to reduce body weight.

Source type: Peer-reviewed study
DOI: 10.1126/scitranslmed.adg1659
Catalogue ID: SNmoj7nwvq-ntrjac

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