Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Pharmacomicrobiomics: Exploiting the Drug-Microbiota Interactions in Antihypertensive Treatment

Huiqing Chen, Jin-Yu Gong, Kai Xing, Mou-Ze Liu, Huan Ren, Jian‐Quan Luo

Frontiers in Medicine · 2022

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Summary

Hypertension is a leading risk factor for cardiovascular diseases and can reduce life expectancy. Owing to the widespread use of antihypertensive drugs, patients with hypertension have improved blood pressure control over the past few decades. However, for a considerable part of the population, these drugs still cannot significantly improve their symptoms. In order to explore the reasons behind, pharmacomicrobiomics provide unique insights into the drug treatment of hypertension by investigating the effect of bidirectional interaction between gut microbiota and antihypertensive drugs. This review discusses the relationship between antihypertensive drugs and the gut microbiome, including changes in drug pharmacokinetics and gut microbiota composition. In addition, we highlight how our curre

Source type
Peer-reviewed study
DOI
10.3389/fmed.2021.742394
Catalogue ID
SNmoj7nxkg-6pjbmc
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