Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Adopting Mechanistic Molecular Biology Approaches in Exposome Research for Causal Understanding

Amy Foreman, Benedikt Warth, Ellen V.S. Hessel, Elliott J. Price, Emma Schymanski, Gaia Cantelli, Helen Parkinson, Helge Hecht, Jana Klánová, Jelle Vlaanderen, Klára Hilscherová, Martine Vrijheid, Paolo Vineis, Rita Araújo, Robert Barouki, Roel Vermeulen, Sophie Lanone, Søren Brunak, Sylvain Sebért, T. Karjalainen

Environmental Science & Technology · 2024

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Summary

Through investigating the combined impact of the environmental exposures experienced by an individual throughout their lifetime, exposome research provides opportunities to understand and mitigate negative health outcomes. While current exposome research is driven by epidemiological studies that identify associations between exposures and effects, new frameworks integrating more substantial population-level metadata, including electronic health and administrative records, will shed further light on characterizing environmental exposure risks. Molecular biology offers methods and concepts to study the biological and health impacts of exposomes in experimental and computational systems. Of particular importance is the growing use of omics readouts in epidemiological and clinical studies. Thi

Source type
Peer-reviewed study
DOI
10.1021/acs.est.3c07961
Catalogue ID
SNmojad181-3jbt0r
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