Pulse Brain · Growing Health Evidence Index
Peer-reviewed

An ensemble penalized regression method for multi-ancestry polygenic risk prediction

Jingning Zhang, Jianan Zhan, Jin Jin, Cheng Ma, Ruzhang Zhao, Jared O’Connell, Yunxuan Jiang, Bertram L. Koelsch, Haoyu Zhang, Nilanjan Chatterjee

Nature Communications · 2024

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Summary

for continuous traits by an average of 70% compared to a state-of-the-art Bayesian method (PRS-CSx) in the African ancestry population. Further, PROSPER is computationally highly scalable for the analysis of large SNP contents and many diverse populations.

Source type
Peer-reviewed study
DOI
10.1038/s41467-024-47357-7
Catalogue ID
SNmojad56o-r6ompa
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