A prospective prostate cancer screening programme for men with pathogenic variants in mismatch repair genes (IMPACT): initial results from an international prospective study

Elizabeth Bancroft, Elizabeth Page, Mark N. Brook, Sarah Thomas, Natalie Taylor, Jennifer Pope, Jana McHugh, Ann-Britt Jones, Questa Karlsson, Susan Merson, Kai Ren Ong, Jonathan Hoffman, Camilla Huber, Lovise Mæhle, Eli Marie Grindedal, Astrid Stormorken, D. Gareth Evans, Jeanette Rothwell, Fiona Lalloo, Angela F. Brady, Marion Bartlett, Katie Snape, Helen Hanson, Paul A. James, Joanne McKinley, Lyon Mascarenhas, Sapna Syngal, Chinedu Ukaegbu, Lucy Side, Tessy Thomas, Julian Barwell, Manuel R. Teixeira, Louise Izatt, Mohnish Suri, Finlay Macrae, Nicola Poplawski, Rakefet Chen‐Shtoyerman, Munaza Ahmed, Hannah Musgrave, Nicola Nicolai, Lynn Greenhalgh, Carole Brewer, Nicholas Pachter, Allan D. Spigelman, Ashraf Azzabi, Brian T. Helfand, Dorothy Halliday, Saundra S. Buys, Teresa Ramón y Cajal, Alan Donaldson, Kathleen A. Cooney, Marion Harris, John McGrath, Rosemarie Davidson, Amy Taylor, Peter Cooke, Kathryn Myhill, Matthew Hogben, Neil K. Aaronson, Audrey Ardern‐Jones, Chris H. Bangma, Elena Castro, David P. Dearnaley, Alexander Dias, Tim Dudderidge, Diana M Eccles, Kate Green, Jórunn E. Eyfjörd, Alison Falconer, Christopher S. Foster, Henrik Grönberg, Freddie C. Hamdy, Oskar T. Johannsson, Vincent Khoo, Hans Lilja, Geoffrey J. Lindeman, Jan Lubiński, Karol Axcrona, Christos Mikropoulos, Anita Mitra, Clare Moynihan, Holly Ní Raghallaigh, Gad Rennert, Rebecca Collier, Lisa K. Adams, Julian Adlard, Rosa Alfonso, Saira Ali, Angela Andrew, Luís Araújo, Nazya Azam, Darran Ball, Queenstone Barker, Alon Basevitch, Barbara Benton, Cheryl Berlin, Nicola Bermingham, Leah H. Biller, Angela Bloss, Matilda Bradford

The Lancet Oncology · 2021

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Summary

BACKGROUND: Lynch syndrome is a rare familial cancer syndrome caused by pathogenic variants in the mismatch repair genes MLH1, MSH2, MSH6, or PMS2, that cause predisposition to various cancers, predominantly colorectal and endometrial cancer. Data are emerging that pathogenic variants in mismatch repair genes increase the risk of early-onset aggressive prostate cancer. The IMPACT study is prospectively assessing prostate-specific antigen (PSA) screening in men with germline mismatch repair pathogenic variants. Here, we report the usefulness of PSA screening, prostate cancer incidence, and tumour characteristics after the first screening round in men with and without these germline pathogenic variants. METHODS: The IMPACT study is an international, prospective study. Men aged 40-69 years wi

Source type: Peer-reviewed study
DOI: 10.1016/s1470-2045(21)00522-2
Catalogue ID: SNmojad5uh-ngtdmu

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