Summary
The SYNTAX trial was a multicentre randomised controlled trial comparing percutaneous coronary intervention with drug-eluting stents versus coronary artery bypass grafting in patients with complex three-vessel or left main coronary artery disease. This 10-year follow-up report presents long-term clinical outcomes, safety, and efficacy data for both treatment strategies, informing evidence-based decision-making in the management of complex coronary artery disease.
UK applicability
The findings are directly applicable to UK cardiovascular practice, as the trial enrolled international centres including United Kingdom sites and evaluated treatment strategies used routinely in the UK National Health Service. The results inform interventional and surgical treatment guidelines for complex coronary disease management in UK hospitals.
Key measures
10-year cumulative incidence of major adverse cardiac and cerebrovascular events (MACCE), all-cause mortality, cardiac mortality, myocardial infarction, stroke, and repeat revascularisation procedures
Outcomes reported
The study compared long-term clinical outcomes (10-year follow-up) between percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) in patients with three-vessel or left main coronary artery disease. Primary endpoints included major adverse cardiac and cerebrovascular events (MACCE), mortality, myocardial infarction, and stroke.
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