Summary
This prospective multicentre observational study of 11,298 heart failure outpatients examined the prevalence and clinical outcomes of isolated and combined moderate-to-severe mitral and tricuspid regurgitation across the ejection fraction spectrum. The findings demonstrate that isolated tricuspid regurgitation was predominantly associated with preserved ejection fraction phenotypes and carried unexpectedly poor prognosis, whilst combined regurgitation burden was highest in reduced ejection fraction patients.
UK applicability
As a European registry study, findings are directly applicable to UK heart failure populations and clinical practice. The prognostic stratification by valve disease pattern may inform risk assessment and monitoring protocols within UK cardiology services and NHS heart failure programmes.
Key measures
Prevalence of isolated mitral regurgitation (MR), isolated tricuspid regurgitation (TR), combined MR/TR, and no MR/TR; odds ratios by ejection fraction category; incident rates of all-cause death, cardiovascular death, and HF hospitalisation
Outcomes reported
The study measured prevalence of isolated and combined mitral and tricuspid regurgitation across the heart failure spectrum, and reported all-cause mortality, cardiovascular mortality, and heart failure hospitalisation rates at 1-year follow-up stratified by regurgitation status.
Topic tags
Dig deeper with Pulse AI.
Pulse AI has read the whole catalogue. Ask about this record, its theme, or how the findings apply to UK farming and policy — every answer cites the underlying studies.