Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Small-diameter artery grafts engineered from pluripotent stem cells maintain 100% patency in an allogeneic rhesus macaque model

Jue Zhang, Diana M. Tabima, David Vereide, Weifeng Zeng, Nicholas J. Albano, Sarah Lyon, Peter J. Nicksic, Ellen C. Shaffrey, Robert E. George, Mitchell D. Probasco, Elizabeth Perrin, Yiyang Xu, Matthew E. Brown, Ron Stewart, Naomi C. Chesler, Lih-Sheng Turng, Samuel O. Poore, Igor I. Slukvin, James A. Thomson, John P. Maufort

Cell Reports Medicine · 2025

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Summary

Autologous vascular grafts, the only clinically approved option for small-diameter (<6 mm) revascularizations, require invasive harvesting and have limited availability and variable quality. To address these challenges, we develop a 3-mm-diameter artery graft by using arterial endothelial cells (AECs) derived from pluripotent stem cells (PSCs). After establishing technologies for pure AEC generation and expanded polytetrafluoroethylene (ePTFE) graft coating, we engineer artery grafts by seeding the inner lumen of ePTFE vascular grafts with either major histocompatibility complex (MHC) mismatched unmodified-wild-type (MHC-WT) AECs or MHC class I/II double knockout (MHC-DKO) AECs. Their function is evaluated in a rhesus arterial interposition grafting model. MHC-WT grafts maintained 100% pat

Source type
Peer-reviewed study
DOI
10.1016/j.xcrm.2025.102002
Catalogue ID
SNmojg07i2-avqxr3
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