Pulse Brain · Growing Health Evidence Index
Peer-reviewed

The right heart perspective in chronic cardiorenal syndrome: the key role of right heart function and tricuspid regurgitation innovation

Xueshi Yin, Long Tang, Jianping Liu, Yongheng Zhang

Frontiers in Cardiovascular Medicine · 2026

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Summary

Cardiorenal syndrome (CRS) refers to the pathophysiological interaction between cardiac dysfunction and kidney injury. Traditional CRS research has focused primarily on the impact of left heart failure on renal function. However, increasing evidence suggests that abnormalities in right heart function, particularly tricuspid regurgitation (TR), critically exacerbate the progression of CRS by promoting renal venous congestion, worsening kidney function, and further aggravating right heart failure. With the aging population and prolonged survival of patients with heart failure, the prevalence of TR has significantly increased and has a substantial impact on prognosis. Therefore, there is an urgent need to reassess the role of TR in heart-kidney interactions. This review summarizes the pathoph

Source type
Peer-reviewed study
DOI
10.3389/fcvm.2025.1710898
Catalogue ID
SNmojj1k3m-mandx3
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