Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Intestinal Microbiota and Derived Metabolites in Myocardial Fibrosis and Postoperative Atrial Fibrillation

Antonio Nenna, Alice Laudisio, Chiara Taffon, Marta Fogolari, Cristiano Spadaccio, Chiara Ferrisi, Francesco Loreni, Omar Giacinto, Ciro Mastroianni, Raffaele Barbato, David Rose, Antonio Salsano, Francesco Santini, Silvia Angeletti, Anna Crescenzi, Raffaele Antonelli Incalzi, Massimo Chello, Mario Lusini

International Journal of Molecular Sciences · 2024

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Summary

= 0.017) were independent predictors of POAF. Also, TMAO was significantly associated with POAF by means of increased fibrosis. Gut microbiome product TMAO is crucial for myocardial fibrosis, which is a key factor for POAF. Patients in preoperative sinus rhythm who will develop POAF have increased genetic expression of pro-fibrotic genes and enhanced fibrosis in histological staining. Elevated TMAO level (≥61.8 ng/mL) is an independent risk factor for POAF.

Subject
Gut microbiome & human health
Source type
Peer-reviewed study
System type
Other
DOI
10.3390/ijms25116037
Catalogue ID
SNmojj1mnv-5tx7mn
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