Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Kumquat Flavonoids Attenuate Atherosclerosis in ApoE<sup>–/–</sup> Mice by Inhibiting the Activation of NLRP3 Inflammasome through Upregulating MicroRNA-145

Linhai Cao, Junli Chen, Hongxia Ni, Xiaoxiao Gong, Ziyan Zang, Hui Chang

Journal of Agricultural and Food Chemistry · 2025

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Summary

(MOVAS cells), KFs were found to inhibit the activation of NLRP3 inflammasome and simultaneously upregulate microRNA-145 (miR-145). In conclusion, our findings suggest that KFs exert their inhibitory effects on NLRP3 inflammasome through upregulating miR-145, thereby alleviating the progression of AS.

Subject
Phytochemicals & bioactive compounds
Source type
Peer-reviewed study
System type
Other
DOI
10.1021/acs.jafc.5c00295
Catalogue ID
SNmojj1pl8-3713hx
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