Maternal high-fat diet during lactation reduces sialylated milk oligosaccharides and shapes early-life microbiota in rat offspring

Summary

and Lachnospiraceae. Levels of faecal SCFAs including acetate, butyrate, isobutyrate, valerate and isovalerate were also increased in HF pups. In humans, maternal obesity only slightly increased DFLNHa concentration in the colostrum. In conclusion, our data suggest that a hyperlipidic diet during lactation may reduce the level of sialylated oligosaccharides in breast milk and alter the abundance of several groups of bacteria in the infant's gut. We also demonstrated that, in humans, obesity did not highly affect levels of HMOs in the colostrum reinforcing previous findings suggesting that being overweight does not influence drastically the HMO profile in breast milk.