Summary
This double-blind, placebo-controlled randomised clinical trial examined whether oral Lactobacillus reuteri supplementation reduces colic symptoms in infants. The trial, conducted in the United States with a large multicentre sample, provides evidence on the efficacy and safety of probiotic intervention in early infant health. The findings contribute to understanding of the role of gut microbiota modulation in alleviating infantile colic.
UK applicability
The findings are directly relevant to UK paediatric and primary care practice, where infantile colic remains a common concern. Results may inform guidance for healthcare providers counselling parents on probiotic supplementation as a potential intervention, though local regulatory and prescribing frameworks differ.
Key measures
Daily crying duration (minutes); colic symptom severity; parental stress and sleep quality; adverse event monitoring
Outcomes reported
The study evaluated the efficacy of Lactobacillus reuteri supplementation in reducing colic symptoms and crying duration in infants aged 2–16 weeks. Outcomes measured included changes in daily crying time, parental quality of life, and adverse events.
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