Summary
This study characterises the secondary metabolome of a recently described Bacillus nakamurai strain (BDI-IS1) through integrated genomic and metabolomic approaches, identifying multiple non-ribosomal peptides and ribosomally-synthesised peptides with antimicrobial properties. Reverse genetic studies demonstrated the involvement of specific metabolites in antagonistic activity. Greenhouse trials showed BDI-IS1 provided biocontrol protection against foliar diseases in tomato and maize comparable to or superior to the reference strain B. velezensis QST713, operating through both direct antibiosis and induced plant defence mechanisms.
Regional applicability
This study was conducted internationally with findings focused on tropical crop disease contexts (early blight and northern leaf blight). Whilst the pathogenic fungi involved (Alternaria solani and Exserohilum turcicum) may not be primary concerns in United Kingdom horticulture, the biocontrol approach and mechanistic insights regarding secondary metabolite production in Bacillus species are potentially relevant to UK integrated pest management strategies and microbial biocontrol development.
Key measures
Secondary metabolite production profiles; in vitro antimicrobial activity; plant disease reduction following root or leaf application; comparative genomics across B. nakamurai strains
Outcomes reported
The study characterised the secondary metabolome of Bacillus nakamurai strain BDI-IS1 through genome mining and metabolomics, and evaluated its biocontrol efficacy in greenhouse trials against early blight in tomato and northern leaf blight in maize.
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