Pulse Brain · Growing Health Evidence Index
Tier 4 — Narrative / commentaryPeer-reviewed

Disease-modifying therapies for Parkinson disease: lessons from multiple sclerosis

Lorraine V. Kalia, Angelica Asis, Nathalie Arbour, Amit Bar‐Or, Riley Bove, Daniel G. Di Luca, Edward A. Fon, Susan H. Fox, Ziv Gan‐Or, Jennifer L. Gommerman, Un Jung Kang, Eric C. Klawiter, Marcus Koch, Shannon Kolind, Anthony E. Lang, Karen K. Lee, Matthew R. Lincoln, Penny A. MacDonald, Martin J. McKeown, Tiago Mestre, Véronique E. Miron, Daniel Ontaneda, Maxime W.C. Rousseaux, Michael G. Schlossmacher, Raphaël Schneider, A. Jon Stoessl, Jiwon Oh

Nature Reviews Neurology · 2024

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Summary

This narrative review, authored by an international cohort of neurology researchers, explores how disease-modifying therapeutic approaches developed for multiple sclerosis may inform treatment strategies for Parkinson disease. The authors synthesise evidence on immunological and neuroprotective mechanisms relevant to both conditions, as suggested by the interdisciplinary author list and journal scope. The work appears designed to bridge two major neurodegenerative disease fields and identify translatable therapeutic principles.

Regional applicability

As a clinical neurology review published in an international journal, the findings and therapeutic recommendations would be applicable to United Kingdom neurology practice and NHS treatment guidelines, particularly in informing clinical trial design and therapeutic development for Parkinson disease management.

Key measures

Therapeutic mechanisms, clinical trial outcomes, and comparative disease-modifying strategies between Parkinson disease and multiple sclerosis

Outcomes reported

The paper examines disease-modifying therapeutic strategies for Parkinson disease by drawing parallels with established approaches in multiple sclerosis research and clinical practice.

Theme
Nutrition & health
Subject
Other / interdisciplinary
Study type
Narrative Review
Study design
Narrative review
Source type
Peer-reviewed study
Status
Published
Geography
International
System type
Human clinical
DOI
10.1038/s41582-024-01023-0
Catalogue ID
SNmp6e745k-4laki3

Topic tags

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