Summary
This review examines the Neurod family of basic Helix-loop-Helix transcription factors, which are highly conserved regulators of central nervous system development and postnatal function. The authors synthesise evidence that the four Neurod family members play critical roles during development of the cerebral cortex and other CNS regions, and discuss emerging evidence linking their dysfunction to human neurological disease.
Regional applicability
This is fundamental neuroscience research without direct application to United Kingdom agricultural or food systems policy. Findings may inform medical research and neurological therapeutics development, but have no direct transferability to farming, soil health or nutrition assessment contexts.
Key measures
Transcriptional regulation mechanisms; Neurod gene expression and function across CNS regions; association of Neurod dysfunction with neurological disorders
Outcomes reported
This review synthesises evidence on the roles of four Neurod family members (Neurod1, Neurod2, Neurod4, Neurod6) in central nervous system development and function. The paper examines their involvement in cerebral cortex, cerebellum, brainstem and spinal cord development, and discusses links between Neurod dysfunction and human neurological disorders.
Topic tags
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