Pulse Brain · Growing Health Evidence Index
Tier 2 — RCT / large cohortPeer-reviewed

Depletion and disruption of dietary fibre: effects on satiety, plasma-glucose, and serum-insulin

Haber GB, Heaton KW, Murphy D, Burroughs LF

Lancet · 1977.0

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Summary

This 1977 Lancet paper by Haber and colleagues investigated how the physical form of dietary fibre — whether intact, mechanically disrupted (as in juice or purée), or depleted — influences satiety and postprandial metabolic responses. Using apples as a model food in what appears to be a controlled crossover design, the study likely demonstrated that fibre disruption and depletion led to faster consumption, reduced satiety, and higher plasma glucose and serum insulin peaks compared to whole fruit. The findings contributed foundational evidence to the hypothesis that the physical structure of food, not merely its chemical composition, is a critical determinant of glycaemic and satiety responses.

UK applicability

Conducted in the UK, this study is directly applicable to UK dietary guidance, particularly regarding recommendations on whole fruit versus fruit juice consumption and the role of food processing in metabolic health outcomes.

Key measures

Satiety ratings; plasma glucose (mmol/L); serum insulin (mU/L); eating rate; caloric intake

Outcomes reported

The study measured the effects of consuming whole, disrupted, and fibre-depleted forms of apples on satiety, plasma glucose levels, and serum insulin response. It likely found that physical disruption or removal of dietary fibre accelerated eating rate, reduced satiety, and produced greater postprandial glucose and insulin excursions.

Theme
Nutrition & health
Subject
Dietary fibre & glycaemic health
Study type
Research
Study design
RCT
Source type
Peer-reviewed study
Status
Published
Geography
UK
System type
Human clinical
DOI
10.1016/s0140-6736(77)90480-5
Catalogue ID
WP0097

Topic tags

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