Pulse Brain · Growing Health Evidence Index
Tier 1 — Meta-analysis / systematic reviewPeer-reviewed

Association between pyrethroid exposure and ADHD in children: meta-analysis

Zhang, Q. et al.

2021

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Summary

This meta-analysis, published in Environmental Science & Pollution Research, synthesises epidemiological evidence on the relationship between pyrethroid pesticide exposure in children and the likelihood of ADHD diagnosis or behavioural symptoms consistent with ADHD. By pooling data from multiple observational studies, it provides a quantitative estimate of the association and likely explores potential dose-response relationships. The findings are relevant to ongoing debates around neurodevelopmental effects of low-level pesticide exposure in children.

UK applicability

Pyrethroids are widely used insecticides in UK agriculture and domestic pest control, and dietary and environmental exposure among UK children is plausible; the findings are therefore relevant to UK public health policy, pesticide regulation under the UK Biocidal Products Regulation, and ongoing reviews by the Health and Safety Executive.

Key measures

Pooled odds ratio (OR) or relative risk (RR) for ADHD diagnosis or symptoms; urinary pyrethroid metabolite concentrations (e.g. 3-PBA); number of studies and participants included

Outcomes reported

The meta-analysis examined the association between pyrethroid pesticide exposure (typically assessed via urinary biomarkers) and the odds or risk of ADHD diagnosis or symptoms in children. It likely reports pooled odds ratios or relative risks across included epidemiological studies.

Theme
Nutrition & health
Subject
Pesticides & human health
Study type
Meta-analysis
Study design
Meta-analysis
Source type
Peer-reviewed study
Status
Published
Geography
International
System type
Human clinical
Catalogue ID
XL0085

Topic tags

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