Summary
Published in Trends in Molecular Medicine in 2023, this narrative review by Parizadeh and Arrieta synthesises current evidence on the relationship between modifiable lifestyle factors and the human gut microbiome. The authors likely discuss how diet, exercise, sleep, and environmental exposures collectively shape microbial diversity and community structure, with consequences for host health. The review situates microbiome modulation as a tractable mechanism through which lifestyle interventions may influence chronic disease trajectories.
UK applicability
Although not UK-specific, the findings are broadly applicable to UK public health contexts, particularly given NHS interest in lifestyle medicine and the growing policy focus on diet-related non-communicable diseases. UK researchers and practitioners can draw on this synthesis to inform dietary and behavioural recommendations aimed at supporting gut microbiome health.
Key measures
Gut microbiome composition (diversity indices, taxon abundance); lifestyle exposure variables (diet quality, physical activity, sleep duration); associations with health outcomes including metabolic and immune markers
Outcomes reported
The paper examines how lifestyle factors — including diet, physical activity, sleep, stress, and antibiotic use — influence the composition and function of the human gut microbiome. It likely synthesises evidence on how microbiome alterations mediate downstream effects on immune function, metabolic health, and disease risk.
Topic tags
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