Pulse Brain · Growing Health Evidence Index
Tier 4 — Narrative / commentaryPeer-reviewed

Essential nutrient interactions: Does low or suboptimal magnesium status interact with vitamin D and/or calcium status?

Rosanoff, A., Dai, Q. and Shapses, S.A.

Advances in Nutrition · 2016

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Summary

This 2016 narrative review by Rosanoff, Dai and Shapses examines the biochemical interactions between magnesium status and both vitamin D and calcium metabolism. The authors synthesise evidence suggesting that suboptimal magnesium status—common in Western diets—may impair vitamin D activation and disrupt calcium homeostasis, implying that magnesium status warrants concurrent clinical evaluation alongside vitamin D and calcium assessment in human nutrition.

Regional applicability

The findings are relevant to UK public health and clinical practice, particularly given evidence of suboptimal magnesium intake in UK populations. The review's conclusions on co-evaluation of magnesium with vitamin D and calcium may inform UK dietary guidelines and supplementation recommendations, although direct UK prevalence data would strengthen local applicability.

Key measures

Magnesium status; vitamin D activation and function; calcium regulatory pathways; interaction mechanisms between these micronutrients

Outcomes reported

The review synthesises evidence on biochemical and functional interactions between magnesium status and vitamin D and calcium metabolism in humans. It examines how suboptimal magnesium status may impair vitamin D activation and calcium regulatory pathways.

Theme
Nutrition & health
Subject
Micronutrients & dietary adequacy
Study type
Narrative Review
Study design
Narrative review
Source type
Peer-reviewed study
Status
Published
Geography
International
System type
Human clinical
DOI
10.3945/an.115.008631
Catalogue ID
XL0201

Topic tags

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