Summary
This review by Hurrell and Egli, published in the American Journal of Clinical Nutrition (2010), synthesises evidence on the role of phytates as the principal dietary inhibitors of iron and zinc absorption in humans. The authors likely draw on human isotope studies and feeding trials to quantify the inhibitory effect of phytic acid across a range of plant foods and dietary contexts. The paper is widely cited in discussions of micronutrient deficiency, particularly in populations reliant on cereal- and legume-based diets.
UK applicability
Although not UK-specific, the findings are broadly applicable to UK dietary contexts, particularly in relation to plant-based and vegetarian diets where cereals, legumes and pulses contribute substantially to iron and zinc intake. The evidence is relevant to UK public health nutrition guidance and food reformulation strategies aimed at improving micronutrient status.
Key measures
Iron absorption (%); zinc absorption (%); phytate-to-iron and phytate-to-zinc molar ratios; fractional mineral absorption estimates
Outcomes reported
The study examined the inhibitory effects of phytic acid (phytate) on the absorption of iron and zinc from plant-based diets, likely reporting dose-response relationships and the influence of phytate-to-mineral molar ratios on bioavailability.
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