Summary
This narrative review, published in Food & Function in 2015, synthesises evidence on the atheroprotective potential of dietary (poly)phenols with a specific focus on their roles in modulating cellular cholesterol metabolism. The authors draw on in vitro, animal, and human study data to elucidate mechanistic pathways through which polyphenols may reduce cardiovascular disease risk. The paper provides a mechanistic framework linking polyphenol-rich dietary patterns to reduced atherogenesis via cholesterol-related cellular processes.
UK applicability
The mechanistic findings are broadly applicable to UK public health and dietary guidance contexts, particularly given ongoing interest in polyphenol-rich foods such as fruits, vegetables, and whole grains within UK dietary recommendations and cardiovascular disease prevention strategies.
Key measures
Cellular cholesterol efflux; LDL receptor expression; cholesterol biosynthesis pathway markers; atheroprotective biomarkers in vitro and in vivo
Outcomes reported
The review examines how dietary (poly)phenols influence cholesterol metabolism at the cellular level, with particular attention to mechanisms relevant to atherosclerosis prevention. It likely covers effects on cholesterol uptake, efflux, and related metabolic pathways in vascular and hepatic cells.
Topic tags
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