Pulse Brain · Growing Health Evidence Index
Tier 1 — Meta-analysis / systematic reviewPeer-reviewed

et al

Reynolds A. et al.

2020

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Summary

Reynolds et al. (2020), published in The BMJ (368:m154), presents a systematic review and meta-analysis synthesising evidence on whole grain consumption and health outcomes across multiple prospective and interventional studies. The paper likely reports a graded, inverse association between whole grain intake and risk of cardiovascular disease, type 2 diabetes, and certain cancers, supporting dietary recommendations to increase whole grain consumption. As part of a broader series informing WHO guidelines on carbohydrate quality, this work situates whole grains within the wider discourse on dietary fibre and chronic disease prevention.

UK applicability

The findings are broadly applicable to UK dietary policy and practice, as UK diets generally fall short of recommended whole grain intakes; the evidence supports existing NHS and Public Health England guidance encouraging whole grain consumption as part of a balanced diet.

Key measures

Relative risk and hazard ratios for mortality and disease incidence; dose-response estimates per daily serving of whole grains; confidence intervals across pooled cohort and intervention data

Outcomes reported

The study examined associations between whole grain intake and a range of health outcomes including cardiovascular disease, type 2 diabetes, colorectal cancer, and all-cause mortality. Risk estimates across prospective cohort studies and trials were pooled to quantify dose-response relationships.

Theme
Nutrition & health
Subject
Dietary patterns & chronic disease
Study type
Meta-analysis
Study design
Systematic review and meta-analysis
Source type
Peer-reviewed study
Status
Published
Geography
Global
System type
Human clinical
Catalogue ID
XL0303

Topic tags

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