Pulse Brain · Growing Health Evidence Index
Tier 3 — Observational / field trialPeer-reviewed

et al

Rautiainen S. et al.

2016

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Summary

This paper by Rautiainen and colleagues, published in the American Journal of Clinical Nutrition in 2016, investigates the relationship between dietary supplement use and mortality outcomes in an adult population. Drawing on prospective cohort data, it likely assesses whether common supplement use — including vitamins and minerals — is associated with increased or decreased mortality risk. The findings are likely to highlight that supplementation outside established deficiency contexts may confer limited or no mortality benefit, and could in some cases be associated with harm.

UK applicability

Although this study was likely conducted in a US population, the findings are broadly applicable to UK public health practice, particularly given ongoing debate around supplement recommendations by NHS and UK dietary guidelines bodies such as SACN.

Key measures

Mortality rates (all-cause and cause-specific); supplement use prevalence; hazard ratios with confidence intervals

Outcomes reported

The study examined associations between dietary supplement use and all-cause or cause-specific mortality in a population cohort, likely reporting hazard ratios or relative risks across supplement types and dosages.

Theme
Nutrition & health
Subject
Dietary supplements & health outcomes
Study type
Research
Study design
Observational cohort
Source type
Peer-reviewed study
Status
Published
Geography
United States
System type
Human clinical
Catalogue ID
XL0613

Topic tags

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