Summary
This influential review, published in The Lancet, provides a comprehensive synthesis of the biological mechanisms driving antimicrobial resistance alongside the ecological, clinical, and policy factors that accelerate its global spread. The authors examine resistance across human health, veterinary, and environmental settings, reflecting a One Health perspective. The paper is widely cited as a foundational reference for understanding AMR as a multisectoral public health challenge.
UK applicability
The paper's findings are directly applicable to the UK, which has a national AMR action plan and where antibiotic use in both human medicine and livestock farming is subject to ongoing regulatory scrutiny. UK agricultural and clinical policy on antibiotic stewardship draws on the mechanistic and epidemiological evidence that reviews such as this synthesise.
Key measures
Resistance mechanisms (enzymatic inactivation, efflux pumps, target modification); drivers of AMR (antibiotic consumption rates, agricultural use, infection control failures); burden of resistant infections
Outcomes reported
The paper examined the biological mechanisms underpinning antimicrobial resistance (AMR) and the key drivers accelerating its emergence and spread, including antibiotic use in human medicine, agriculture, and the environment. It likely reported on resistance gene dissemination, selective pressure dynamics, and cross-sectoral transmission pathways.
Topic tags
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