Summary
Published in Physiological Reviews in 2018, this article by Wolfgang Langhans provides a comprehensive narrative review of how mammals sense dietary nutrients and translate those signals into coordinated metabolic responses. The review likely synthesises evidence on peripheral and central nutrient-sensing mechanisms, including gut-derived hormones, vagal afferents, and intracellular nutrient detectors such as mTOR and AMPK pathways. It represents a substantial synthesis of the field and is likely intended as a reference work for researchers in nutritional physiology and metabolic medicine.
UK applicability
As a mechanistic review of fundamental mammalian physiology, the findings are fully applicable to UK research, clinical nutrition, and public health contexts, informing understanding of diet-related metabolic conditions such as obesity and type 2 diabetes.
Key measures
Mechanistic pathways of nutrient sensing; hormonal and neural signalling cascades; metabolic regulatory responses including energy balance and glucose homeostasis
Outcomes reported
The review examines how the body detects macronutrients and micronutrients and translates those signals into metabolic and physiological responses; it likely covers gut-brain signalling, hormonal regulation, and energy homeostasis.
Topic tags
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