Pulse Brain · Growing Health Evidence Index
Tier 4 — Narrative / commentaryPeer-reviewed

et al

Rein M.J. et al.

2013

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Summary

This review, published in the American Journal of Clinical Nutrition, examines the bioavailability of flavonoids — a broad class of plant-derived polyphenolic compounds — with particular attention to the physiological and dietary factors that govern their absorption and metabolism in humans. The paper likely synthesises evidence on how food matrix composition, processing, and gut microbial activity modulate flavonoid bioavailability and downstream biological effects. It is a substantive reference in the field of nutritional biochemistry, informing understanding of how dietary flavonoid intake translates into physiological benefit.

UK applicability

Whilst not UK-specific, the findings are broadly applicable to UK dietary guidance and public health nutrition, given that flavonoid-rich foods such as berries, apples, onions, and tea are prominent in UK diets and feature in nutrient density discussions relevant to food policy.

Key measures

Flavonoid absorption rates; plasma and urinary flavonoid metabolite concentrations; factors modifying bioavailability (food matrix, processing, gut microbiota)

Outcomes reported

The study examined the bioavailability of dietary flavonoids, likely reporting on factors such as food matrix effects, gut microbiota, and metabolic transformation that influence the absorption and biological activity of flavonoid compounds in humans.

Theme
Nutrition & health
Subject
Phytonutrients & dietary bioavailability
Study type
Narrative Review
Study design
Narrative review
Source type
Peer-reviewed study
Status
Published
Geography
International
System type
Human clinical
Catalogue ID
XL1025

Topic tags

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