Summary
This paper, published in the Journal of Clinical Investigation, investigated ceramide synthase 6 as a potential driver of metastasis-prone phenotype in lung cancer cells. However, the corresponding author subsequently notified the journal that re-analysis of the correct patient dataset did not demonstrate a significant difference in CERS6 expression between adenocarcinomas with definite invasive growth and those with negligible or absent invasive growth, prompting an institutional investigation.
UK applicability
This work is not applicable to UK farming systems, soils, or agricultural practice, as it concerns molecular oncology and lung cancer biology rather than food production or farming systems.
Key measures
CERS6 expression levels in human lung adenocarcinoma tissue samples stratified by invasive growth status (definite vs. focal/none)
Outcomes reported
The study investigated ceramide synthase 6 (CERS6) expression as a potential biomarker associated with invasive growth phenotype in lung adenocarcinomas. However, upon re-analysis of patient data, no significant difference in CERS6 expression was found between adenocarcinomas with definite invasive growth versus those with focal or absent invasive growth.
Topic tags
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