Pulse Brain · Growing Health Evidence Index
Tier 3 — Observational / field trialPeer-reviewed

Redefining adequate margins in oral squamous cell carcinoma: outcomes from close and positive margins

Prateek Jain, Rajeev Sharan, Kapila Manikantan, Gary M. Clark, Sanjoy Chatterjee, Indranil Mallick, Paromita Roy, Pattatheyil Arun

European Archives of Oto-Rhino-Laryngology · 2020

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Summary

This retrospective clinical study reassesses traditional definitions of surgical margin adequacy in oral squamous cell carcinoma by comparing oncological outcomes between patients with close or positive margins and those with conventionally adequate margins. The findings, as suggested by the title, may indicate that current margin guidelines warrant reconsideration in light of actual patient outcomes. The work contributes to evidence-based refinement of surgical standards in head and neck oncology practice.

UK applicability

The findings may inform UK head and neck surgical practice and guidelines (such as those from the British Association of Head and Neck Oncologists), though applicability depends on whether the Indian patient cohort's demographics, tumour biology, and adjuvant treatment patterns align with UK practice.

Key measures

Surgical margin status (close, positive, or adequate); recurrence-free survival; overall survival; locoregional recurrence rates

Outcomes reported

The study compared oncological outcomes, including recurrence rates and survival, between patients with close or positive surgical margins versus those with conventionally adequate margins in oral squamous cell carcinoma treatment.

Theme
Nutrition & health
Subject
Other / interdisciplinary
Study type
Research
Study design
Retrospective cohort
Source type
Peer-reviewed study
Status
Published
Geography
India
System type
Human clinical
DOI
10.1007/s00405-019-05779-w
Catalogue ID
BFmoicpf59-qsx72s

Topic tags

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