Pulse Brain · Growing Health Evidence Index
Tier 3 — Observational / field trialPeer-reviewed

<i>In vivo</i>simultaneous imaging with<sup>99m</sup>Tc and<sup>18</sup>F using a Compton camera

Makoto Sakai, Mitsutaka Yamaguchi, Yuto Nagao, Naoki Kawachi, Mikiko Kikuchi, Kota Torikai, Tomihiro Kamiya, Shin’ichiro Takeda, Shin Watanabe, Tadayuki Takahashi, Kazuo Arakawa, Takashi Nakano

Physics in Medicine and Biology · 2018

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Summary

This paper describes the development and validation of a Si/CdTe Compton camera as a multi-tracer imager capable of simultaneously imaging both SPECT and PET probes in vivo. The authors demonstrate that their device achieves imaging consistency with conventional methods whilst reducing cross-talk artefacts inherent in traditional collimated Anger cameras. The results support the feasibility of advancing this technology towards human clinical trials.

UK applicability

This is a physics and instrumentation development paper with no direct application to UK farming systems, soil health, or food production. It falls outside the scope of Vitagri's Pulse Brain catalogue.

Key measures

Image quality, cross-talk artifacts, consistency with PET images and well counter measurements, simultaneous imaging of ⁹⁹ᵐTc and ¹⁸F tracers

Outcomes reported

The study demonstrated that a Si/CdTe Compton camera can simultaneously image two different nuclear medicine tracers (⁹⁹ᵐTc and ¹⁸F) in vivo with results consistent with conventional PET imaging and well counter measurements. The system achieved multi-tracer imaging capability with reduced cross-talk artifacts compared to conventional Anger cameras.

Theme
Measurement & metrics
Subject
Measurement methods & nutrient profiling
Study type
Research
Study design
Laboratory / in vivo validation study
Source type
Peer-reviewed study
Status
Published
System type
Laboratory / in vitro
DOI
10.1088/1361-6560/aae1d1
Catalogue ID
BFmokjnswo-12pdxr

Topic tags

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