Pulse Brain · Growing Health Evidence Index
Tier 3 — Observational / field trialPeer-reviewed

SENECA study: staging endometrial cancer based on molecular classification

Enrique Chacón, Félix Boria, R Rajagopalan Lyer, Francesco Fanfani, Mario Malzoni, Petra Bretová, Ana Luzarraga Aznar, Robert Fruscio, Marcin Jędryka, Richárd Tóth, Anna Myriam Perrone, Athanasios Kakkos, Ignacio Cristóbal Quevedo, Luigi Congedo, Vanna Zanagnolo, Sergi Fernández-González, Beatriz Ferro, Fabrice Narducci, T Hovhannisyan, Elif Akşahin, L. M. Cardenas, M Reyes Oliver, Gonzalo Nozaleda, Marta Arnáez, Marcin Misiek, Annamaria Ferrero, F Pain, Janire Zarragoitia, C. Díaz, Lorenzo Ceppi, Shamsi Mehdiyev, Fernando Roldán-Rivas, Alberto Rafael Guijarro‐Campillo, Joana Amengual, Nabil Manzour, Luisa Sánchez‐Lorenzo, Jorge M. Núñez‐Córdoba, Antonio González-Martı́n, José Ángel Mínguez, Luis Chiva, cecilia darin, Rychlik Agnieszka, Ester Miralpeix, Roberto Berretta, Natalia Palasz, Duska Beric, Dimitrios Tsolakidis, Soledad Fidalgo, Richard Schwameis, S. P. Somashekhar, İbrahim Yalçın, Radovan Pilka, Çağatay Taşkıran, Despoina Myoteri, Estibaliz Iza Rodriguez, Dariusz Wydra, Sílvia Catot, Mathias K. Fehr, Frédéric Goffin, María Luisa Ramos Ibarra, Stamatios Petousis, E Moratalla Bartolomé, Mareike Bommert, Alfonso Quesada, Shamistan Aliyev, Sara Iacoponi, Inmaculada Lozano, Krzysztof Nowosielski, Ioannis Kalogiannidis, Lampe Bjourn

International Journal of Gynecological Cancer · 2024

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Summary

The SENECA study, as suggested by the title and journal, appears to investigate molecular classification approaches for endometrial cancer staging across multiple international gynaecological centres. The research likely evaluates whether molecular markers provide improved prognostic or therapeutic classification compared with conventional histopathological staging in endometrial cancer cohorts. This multicentre approach suggests an effort to validate molecular staging frameworks in clinical practice.

UK applicability

If the molecular classification framework demonstrates clinical utility, findings may inform UK gynaecological oncology practice and NHS diagnostic pathways for endometrial cancer. However, applicability depends on whether the study's cohorts and molecular platforms align with those available in UK NHS laboratories and whether recommendations are adopted by NICE or relevant UK cancer networks.

Key measures

Molecular classification categories, cancer staging, prognostic stratification, clinical outcomes in endometrial cancer

Outcomes reported

The study appears to evaluate molecular classification schemes for staging endometrial cancer and their clinical utility in gynaecological cancer management. The SENECA study likely assessed how molecular biomarkers or genetic classifications can improve prognostic stratification and treatment planning in endometrial cancer patients.

Theme
General food systems / other
Subject
Other / interdisciplinary
Study type
Research
Study design
Observational cohort
Source type
Peer-reviewed study
Status
Published
Geography
International
System type
Human clinical
DOI
10.1136/ijgc-2024-005711
Catalogue ID
BFmokjnvkq-i8mdzi

Topic tags

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