Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Respiratory viral infections awaken metastatic breast cancer cells in lungs

Shi B. Chia, Bryan Johnson, Junxiao Hu, Felipe Valença-Pereira, Marc Chadeau‐Hyam, Fernando Guntoro, Hugh Montgomery, Meher P. Boorgula, Varsha Sreekanth, Andrew Goodspeed, Bennett Davenport, Marco De Dominici, Vadym Zaberezhnyy, Wolfgang E Schleicher, Dexiang Gao, Andreia N. Cadar, Lucia Petriz-Otaño, Michael Papanicolaou, Afshin Beheshti, Stephen B. Baylin, Joseph W. Guarnieri, Douglas C. Wallace, James C. Costello, Jenna M. Bartley, Thomas E. Morrison, Roel Vermeulen, Julio A. Aguirre‐Ghiso, Mercedes Rincón, James DeGregori

Nature · 2025

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Summary

T cell activation and cytotoxicity. Crucially, these experimental findings align with human observational data. Analyses of cancer survivors from the UK Biobank (all cancers) and Flatiron Health (breast cancer) databases reveal that SARS-CoV-2 infection substantially increases the risk of cancer-related mortality and lung metastasis compared with uninfected cancer survivors. These discoveries underscore the huge impact of respiratory viral infections on metastatic cancer resurgence, offering new insights into the connection between infectious diseases and cancer metastasis.

Subject
Other / interdisciplinary
Source type
Peer-reviewed study
System type
Other
DOI
10.1038/s41586-025-09332-0
Catalogue ID
BFmokjo2bz-11z3k7
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