Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Multitask prediction of organ dysfunction in the intensive care unit using sequential subnetwork routing

Subhrajit Roy, Diana Mincu, Eric Loreaux, Anne Mottram, Ivan Protsyuk, Natalie Harris, Yuan Xue, Jessica Schrouff, Hugh Montgomery, Alistair Connell, Nenad Tomašev, Alan Karthikesalingam, Martin Seneviratne

Journal of the American Medical Informatics Association · 2021

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Summary

OBJECTIVE: Multitask learning (MTL) using electronic health records allows concurrent prediction of multiple endpoints. MTL has shown promise in improving model performance and training efficiency; however, it often suffers from negative transfer - impaired learning if tasks are not appropriately selected. We introduce a sequential subnetwork routing (SeqSNR) architecture that uses soft parameter sharing to find related tasks and encourage cross-learning between them. MATERIALS AND METHODS: Using the MIMIC-III (Medical Information Mart for Intensive Care-III) dataset, we train deep neural network models to predict the onset of 6 endpoints including specific organ dysfunctions and general clinical outcomes: acute kidney injury, continuous renal replacement therapy, mechanical ventilation, v

Subject
Other / interdisciplinary
Source type
Peer-reviewed study
System type
Other
DOI
10.1093/jamia/ocab101
Catalogue ID
BFmokjo2bz-yvhjg3
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